Long-read sequencing reveals a 4.4 kb tandem repeat region in the mitogenome of Echinococcus granulosus (sensu stricto) genotype G1

L Kinkar; PK Korhonen; H Cai; CG Gauci; MW Lightowlers; U Saarma; DJ Jenkins; J Li; J Li; ND Young; RB Gasser

Journal article

Long-read sequencing reveals a 4.4 kb tandem repeat region in the mitogenome of Echinococcus granulosus (sensu stricto) genotype G1

L Kinkar, PK Korhonen, H Cai, CG Gauci, MW Lightowlers, U Saarma, DJ Jenkins, J Li, J Li, ND Young, RB Gasser

Parasites and Vectors | BMC | Published : 2019

DOI: 10.1186/s13071-019-3492-x

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Abstract

Background: Echinococcus tapeworms cause a severe helminthic zoonosis called echinococcosis. The genus comprises various species and genotypes, of which E. granulosus (sensu stricto) represents a significant global public health and socioeconomic burden. Mitochondrial (mt) genomes have provided useful genetic markers to explore the nature and extent of genetic diversity within Echinococcus and have underpinned phylogenetic and population structure analyses of this genus. Our recent work indicated a sequence gap (> 1 kb) in the mt genomes of E. granulosus genotype G1, which could not be determined by PCR-based Sanger sequencing. The aim of the present study was to define the complete mt genom..

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University of Melbourne Researchers

Pasi Korhonen Author

Charles Gauci Author

Marshall Lightowlers Author

Neil Young Author

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Awarded by Australian Research Council

Funding Acknowledgements

Research funding from the Australian Research Council (RBG et al.) and the Australian National Health and Medical Research Council (grant GTN1105448; MWL) is gratefully acknowledged.